The use of methylthioadenosine phosphorylase activity to select for human chromosome 9 in interspecies and intraspecies hybrid cells
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The use of methylthioadenosine phosphorylase activity to select for human chromosome 9 in interspecies and intraspecies hybrid cells.
Methylthioadenosine phosphorylase (MTAP) is an enzyme that functions in a salvage pathway for adenine synthesis. The locus that encodes MTAP activity has been mapped to human chromosome 9 (9q12-9pter) by analysis of mouse x human somatic cell hybrids. Cells that have MTAP activity will stop proliferating, and eventually die in the presence of azaserine, an inhibitor of de novo purine synthesis,...
متن کاملAssignment of the gene for methylthioadenosine phosphorylase to human chromosome 9 by mouse-human somatic cell hybridization.
The purine and polyamine metabolic enzyme methylthioadenosine (MeSAdo) phosphorylase is abundant in normal cells and tissues but is lacking from many human and murine malignant cell lines and from cells of some human leukemias in vivo. To explore the genetic control of MeSAdo phosphorylase expression, we measured levels of the enzyme in somatic cell hybrids prepared by fusing MeSAdo phosphoryla...
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این تحقیق به منظور بررسی رابطه بین میزان استراتژیهای خود-تنظیم شده یادگیری و تمایل به ایجاد ارتباط دانشجویان زبان انگلیسی انجام شده است.علاوه بر این،روابط و کنش های موجود بین ریزسنجه های استراتژیهای خود-تنظیم شده یادگُیری ، مهارت نگارش و تمایل به برقراری ارتباط و همچنین تاٍثیرجنسیت دانشجویان زبان انگلیسی در استراتژیهای خود-تنظیم شده یادگیری و تمایل به برقراری ارتباط آنها مورد بررسی قرار گرفته شد.
15 صفحه اولDeficiency of methylthioadenosine phosphorylase in human leukemic cells in vivo.
Cells from 20 patients with leukemia and 9 with solid tumors were assayed for the enzyme methylthioadenosine phosphorylase, which function in both purine and polyamine metabolism in rapidly dividing cells. As determined by autoradiography of viable cells, and by direct enzymatic analysis, samples from one individual with pre-T-cell acute lymphoblastic leukemia and one with common acute lymphobl...
متن کاملDeficiency of methylthioadenosine phosphorylase in human leukemic cells
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ژورنال
عنوان ژورنال: Somatic Cell and Molecular Genetics
سال: 1994
ISSN: 0740-7750,1572-9931
DOI: 10.1007/bf02254764